Macquarie University Neuroinflammation Research Group

Tryptophan degradation through the kynurenine pathway is involved neuroinflammation and is a key player in immuno-regulation. Donate: goto. mq /asamdonate

Over the last three decades, tryptophan research has progressively moved from an “obscure” to a primary field of research.

Interest in tryptophan metabolism and thus the number of publications has been growing concomitantly and almost exponentially. Looking at Pubmed today (November 2014), the overall number of publications about tryptophan, indoleamine 2, 3 dioxygenase (IDO), and the kynurenine pathway has been rising significantly.

Over the last 5 years, our research group has become one of the worlds leading group working on neuroactive (toxic or protective) metabolites derived from tryptophan. We are now very well respected in this field. Our large number of collaborations are testimonies of our unique expertise and leadership in the field of neuroinflammation, neurotoxicity and especially tryptophan metabolism (kynurenine pathway).

Our group has demonstrated the involvement of tryptophan and its metabolites in both physiological and pathological conditions including Alzheimer's disease, multiple sclerosis, Amyotrophic lateral sclerosis depression, breast cancers, brain tumours, suicide, autism, schizophrenia. . .

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